Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy male subjects.
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چکیده
منابع مشابه
Pharmacokinetics of oral fumarates in healthy subjects.
AIMS To characterize the pharmacokinetics of fumarates in healthy subjects. METHODS Ten subjects received a single fumarate tablet (containing 120 mg of dimethylfumarate and 95 mg of calcium-monoethylfumarate) in the fasted state and after a standardized breakfast in randomized order. Prior to and at fixed intervals after the dose, blood samples were drawn and the concentrations of monomethyl...
متن کاملMultiple-dose pharmacokinetics of intravenous telavancin in healthy male and female subjects.
OBJECTIVES The aim of this study was to assess the steady-state pharmacokinetic parameters of telavancin, an investigational bactericidal lipoglycopeptide, after intravenous (iv) administration to healthy male and female subjects. PATIENTS AND METHODS In a randomized, double-blind, parallel-group, gender-stratified, two-dose study, 79 adult subjects received three daily 60 min iv infusions of...
متن کاملPharmacokinetics and metabolism of lumiracoxib in healthy male subjects.
Lumiracoxib (Prexige; 2-[(2-fluoro-6-chlorophenyl)amino]-5-methyl-benzeneacetic acid) is a novel, chemically distinct cyclooxygenase-2 selective inhibitor, which has been developed for the treatment of osteoarthritis, rheumatoid arthritis, and acute pain. The absorption, metabolism, disposition, and mass balance of [14C]lumiracoxib were investigated in four healthy male subjects after a single ...
متن کاملPosaconazole Pharmacokinetics in Healthy Cats after Oral and Intravenous Administration
BACKGROUND Posaconazole is the most active available azole antifungal drug, but absorption and pharmacokinetics are not available to guide dosing regimens in cats. OBJECTIVE To determine the pharmacokinetics of posaconazole in cats given an IV solution and PO suspension. ANIMALS Six healthy, adult research cats. METHODS After a 12-hour fast, each cat received 15 mg/kg of posaconazole PO s...
متن کاملPharmacokinetics of Oral and Intravenous Paracetamol (Acetaminophen) When Co-Administered with Intravenous Morphine in Healthy Adult Subjects
BACKGROUND AND OBJECTIVE Several features favor paracetamol (acetaminophen) administration by the intravenous rather than the oral route in the postoperative setting. This study compared the pharmacokinetics and bioavailability of oral and intravenous paracetamol when given with or without an opioid, morphine. METHODS In this randomized, single-blind, parallel, repeat-dose study in healthy ad...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1991
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1991.tb05606.x